The Manly Sea Eagles host the Cronulla Sharks in a crucial clash at 4 Pines Park.
Reuben Garrick has been ruled out for the year, with Tolutau Koula moving from wing to full-back for Manly.
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Alfred Smalley is the new face on the wing for the hosts.
Andrew Davey was ruled out with Ethan Bullemor starting in the back row and Kurt de Luis joining the bench.
Jake Trbojevic has been replaced by Dylan Walker after being ruled out for the season.
For the Sharks, Kade Dykes was ruled out with a calf injury with Lachlan Miller moving from wing to fullback and Matt Ikuvalu coming on to the wing.
Teig Wilton is also out, with Braydon Trindall taking his place on the pin.
The fourth-placed Sharks can move up to third and finish in the top four with a win, while the Sea Eagles need to win to keep their slim hopes in the final alive.
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